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PIO, GLP-1R agonists, SGLT2 inhibitors and NAFLD: pathophysiological background PIO PIO, currently the only thiazolidinedione (TZD) in clinical practice, is a potent exogenous agonist of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-) and to a lesser extent, PPAR- [17, 44]

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DSIP is studied in sleep-wake and stress-response pathway models