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Stop taking your medication and call 911 or go to the emergency department if you experience any of the following: Severe, persistent stomach pain that may radiate to your back (especially with vomiting), as this could indicate pancreatitis

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It should also be used with caution in people with a history of pancreatitis or severe kidney disease

Vasireddi N et al

Unlike semaglutide, which targets a single receptor, retatrutide simultaneously activates three metabolic pathways