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NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools

Common metabolic pathways involved in ferroptosis, such as (seleno) thiol metabolism, mitochondrial respiration iron handling, mevalonate pathway, and fatty acid metabolism, directly impact cellular sensitivity to lipid peroxidation and ferroptosis

Its important to note that initial weight loss might include water weight, and achieving long-term fat loss requires ongoing commitment to healthy habits

Jiang L, Diaz PT, Best TM, Stimpfl JN, He F, Zuo L

However, longer isn't always better