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Meanwhile, matched control members saw a $416 (3%) decrease in costs from $11,955 pre-treatment to $11,539 post-treatment

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LA pre-treatment (at 1:8000 ratio, with the wash-out step) did not affect the c-met binding-affinity of HGF before or after exposure to peroxynitrite at the same 1:2000 ratio as the LASSS pre-treatment (Figure 1d, lanes 4 and 7 )

The title for Figure 4 should be reconsidered as the term "mutually opposite signal modulation" is unclear and/or does not reflect the description to follow. Response: We have replaced the term mutually opposite signal modulation with: amplification of MC3R signaling and attenuation of GHSR1a signaling For Figure 5, the figure legend should clarified if 5-HT2c-GHSR1a dimerization produces reduced Ca++ accumulation with (as appears to be implied by the figure) or without ligand for each receptor. Response: To make it clearer that the 5-HT2C ligand is not required, while the ghrelin ligand is, we have changed the description to read: When dimerized with 5-HT2C, GHSR1a displays a 65% reduction in ghrelin-induced Ca2+ accumulation, with this effect not requiring the presence of a 5-HT2C ligand. Reviewer #2: The review includes an excellent explanation of GSHR1a dimerization with other receptors at the cellular and molecular level and also does a good job of explaining technical aspects of this type of work