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Positive and negative outcome analyses We then performed positive outcome analyses, and found markedly increased rates of nausea after GLP-1 RAs treatment (aHR: 1.47, 95% CI 1.33-1.62) as a reported complication

Periorbital hyperpigmentation can be caused by shallow vascularization or thin skin in the infraorbital region, hyperpigmentation due to atopic or contact dermatitis, familial predisposition, symptomatic tear troughs, localized shadowing from skin laxity, excessive sun exposure, smoking, sleep deprivation, and fatigue (Citation2,Citation8)

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