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Within five years of chronic L-DOPA treatment, 40%-50% of patients will develop dyskinesias and motor fluctuations

NICE first recommended the drug in draft guidance 2022, after a clinical trial of just under 2000 volunteers found that people lost on average 12% more weight with semaglutide alongside supervised weight loss coaching (BMJ 2023;380:556)

The small size of the study implies a possible association between switching from liraglutide OD or dulaglutide OW to semaglutide OW and further reductions in HbA1c, weight, and BMI in patients with T2DM

suggests that exposure to these peptides may modulate intracellular signaling cascades involved in angiogenesis and the regulation of inflammatory mediators in research models

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