Benefits include: Reduction of saddlebags on outer thighs Decreased inner thigh fullness Less chafing between thighs Improved leg contour Thigh treatments typically require 4-6 sessions for noticeable improvement due to the density of fat in these areas
phase 3 trials ongoing as of 2025 Best phase 2 weight loss (retatrutide) / 24.2% at 48 weeks, 12 mg dose Best phase 3 weight loss (tirzepatide) / 22.5% at 72 weeks, 15 mg dose Combination evidence / zero published controlled trials Primary combination risk / additive nausea, vomiting, potential pancreatitis Switching rationale / inadequate response or tolerability on tirzepatide Guideline position on combining / no major guideline endorses dual-incretin stacking What Are Mounjaro and Retatrutide, and How Do They Differ
Nutrition considerations Eating enough protein is crucial when taking Wegovy, and this is even more important for MS patients: Diet: Eat a diet based on whole foods that minimises ultra-processed foods Protein: Aim for 30-40g of protein at each meal to preserve muscle mass
When a research timeline extends past six weeks, common practice is splitting the reconstituted solution into single-use volumes and freezing them at 20 C immediately
Doctors may require you to try other options before moving on to bariatric surgery