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The researchers suggest that changes in gut microbiome composition, particularly involving Akkermansia muciniphila and Parabacteroides distasonis , may explain the effects on GLP-1 and other gut-brain signaling molecules

cycling protocols (e.g., 8 weeks on, 48 weeks off) are commonly employed [7]

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Peer review Peer review information Nature Chemical Biology thanks Alejandra Tomas and the other, anonymous reviewers for their contribution to the peer review of this work

Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation