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Provider Assessment and Genetic Context: Who Should Pursue GLP-1 Without a Gallbladder Qualified healthcare providers should evaluate medical history, current GI symptoms, liver enzyme trends, and BMI or glycemic status before recommending GLP-1

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Mechanistic studies indicated that these effects were not driven by acute insulinotropic activity, but by -cell preservation and enhanced glucose uptake

Supplementary figure E shows the cumulative incidence curves for serious renal events, with a lower cumulative incidence for the GLP-1 receptor agonist-SGLT-2 inhibitor combination up to two years and the crossing thereafter