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Risk of bias assessment The Cochrane Collaborations risk of bias tool was employed to assess the risk of bias for each study (Reference Higgins, Altman and Gtzsche19)

Additionally, long non-coding RNA (LncRNA) PVT1 is elevated in the plasma of CIRI patients and can regulate TfR1 expression through the LncRNA PVT1/miR214 axis, inducing ferroptosis (Lu et al., 2020)

Theoretical concerns exist for individuals with active cancer due to angiogenic properties, though research hasn't identified increased cancer risk

This peptide is produced by a specialized peptide laboratory based in the EU

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