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For patients who have a clear clinical goal and a protocol that matches it, committing to three cycles upfront is both the more economical and the more clinically sound decision

25 Castelli MC, Friedman K, Sherry J et al (2011) Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study

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The date of all these recommendations is August 2007