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Under hypoxic conditions, the inhibition of PHDs activity results in HIF- accumulation and translocation to the nucleus, which, together with the HIF- subunit forms, can activate transcription factors (HIF-1, HIF2, or HIF-3) [141]
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[8] [9] Patient Selection and Indications Anti-obesity medications are generally indicated as adjuncts to lifestyle intervention in adults with BMI 30 kg/m 2 , or BMI 27 kg/m 2 with at least one weight-related complication such as diabetes mellitus type 2, hypertension, dyslipidemia, obstructive sleep apnea, metabolic dysfunction-associated steatohepatitis, heart failure with preserved ejection fraction, or established cardiovascular disease
Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders
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