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As Healio previously reported, in the main results of SOUL, oral semaglutide (Ozempic pill, Novo Nordisk) reduced risk for major adverse cardiovascular events by 14% compared with placebo in high-risk adults with type 2 diabetes regardless of SGLT2 inhibitor use

Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)