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This isnt pessimism
Glucagon-like peptide-1 as a multi-faceted modulator of inflammatory pathways and oxidative stress
At 12 months, the SEMALEAN study found an average weight loss of 13%, with 59% of patients having achieved 10% body weight reduction
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second, focusing on high-risk cohorts, such as patients with MASH-related compensated cirrhosis, using dynamic contrast-enhanced ultrasound (DCE-US) to monitor de novo nodule emergence and evolution (e.g., arterial phase hyperenhancement) as surrogate endpoints for preliminary chemopreventive assessment
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