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Kalluri R, LeBleu VS

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When we reduce visceral (active) fat while preserving or building muscle, we: Improve insulin sensitivity Lower inflammatory burden Improve lipid markers Support cognitive protection Lower high blood pressure Reduce long-term disease risk Losing more weight through improved body composition, especially by targeting active fat, can have greater long-term health benefits, including better maintenance of weight loss and reduced risk of conditions like diabetes and heart disease

More visible changes in body composition and energy levels typically appear between two to four months, with the most significant metabolic improvements occurring between four to six months as the dose reaches a therapeutic level