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An important exploratory outcome measured in the initial 41-day Phase 2a study was the effect of cotadutide treatment on liver fat reduction as measured by MRI, with a 39.12% reduction was observed in the treatment group compared to 19.51% in placebo group (83)

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FDA approval requires a number of things, which include but are not limited to: proving the drug is safe, proving it works for the intended purpose, and showing it can be manufactured at scale

These washout periods can be anywhere from 3-60 days, depending on the specific glucocorticoid used and whether it was oral, intramuscular, or a local injection

GLP-1 medications can feel intense if the starting dose is too high