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However, most evidence comes from animal studies, with limited data from human trials

Nevertheless, despite demonstrating potent in vivo effects, neither study performed side-by-side dose-response benchmarking against clinical ACE inhibitors (e.g., lisinopril or captopril) under identical assay conditions

Several studies have shown that tirzepatide reduces insulin resistance, improves glycemic control, and lowers inflammatory biomarkers, including C-reactive protein and IL-6 (46, 47)

Psychiatry 78, 702710

What the Regulatory Classification Tells Us These medications have historically been treated similarly to Pregnancy Category C drugs: animal studies showed potential risks, and we dont yet have robust human data to know what that means for human pregnancies