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The Institute for Clinical and Economic Review (ICER) in 2025 noted that price reductions and long-term benefits have improved GLP-1 cost-effectiveness relative to older assumptions ( [70] ), yet insurers still face high absolute spend
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Additionally, the epigenetic landscape is remodelled as a result of the altered expression or activity of histone methyltransferases (HMTs) and demethylases (KDMs), two enzymes that control histone methylation
Data on the safety and efficacy of such therapies over decades are lacking, creating uncertainty about their role in chronic use, Roberts says
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