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Since SARS-CoV-2 activates mitochondrial ROS-mediated feedback loops that produce long-term changes in the redox status and endothelial function of the host, leading to cardiovascular disease and lung injury (Chang et al., 2021), and endothelial cells are key players in inflammatory pathologies, such as acute respiratory distress syndrome, thrombosis, and atherosclerosis
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Evidence by indication and route Dermatologic skin lightening/melasma Topical and oral: Several small randomized, placebo-controlled trials report reductions in melanin index and improvements in skin properties over 812 weeks, with mostly mild adverse events
The difference is not just regulatory
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