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The dual mechanism of tirzepatide tends to produce greater weight loss in clinical trials, approximately 20% to 25% body weight reduction compared to 15% to 17% for semaglutide at maximum doses
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Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity
Evidence for this action has been demonstrated in mice (Fridolf et al., 1991), rats (de Heer et al., 2008), dogs (Freyse et al., 1997), and humans in vivo (Hare et al., 2009), as well as in intact isolated mouse islets (De Marinis et al., 2010)
