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Acute opioid withdrawal is stressful and stimulates the hypothalamuspituitaryadrenal (HPA) axis, leading to increases in pituitary pro-opiomelanocortin mRNA, adrenocorticotropic hormone (ACTH), and adrenal cortisol release [15]

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Gastrointestinal mucosal protection explored in models of gut mucosal injury and inflammatory bowel research for cytoprotective properties