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Safety monitoring should account for several important risks: Diabetic retinopathy : Patients with existing retinopathy should be monitored closely, particularly if experiencing rapid improvements in blood glucose levels, as this can temporarily worsen eye complications

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In a 2-year trial, acute pancreatitis was confirmed by adjudication in 8 semaglutide-treated patients (0.27 cases per 100 patient years) and 10 placebo-treated patients (0.33 cases per 100 patient years), both on a background of standard of care