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Instead of increasing blood flow directly, PT-141 activates melanocortin receptors (MC3R and MC4R) in the central nervous system[2]
However, using a novel Nb37-based BRET approach to monitor activation of endogenous G proteins close to GLP-1R, we demonstrate here that exendin-4-C16 shows increases in G s activation in spite of its lower mini-G s recruitment efficacy
Read about the weight loss drugs currently in clinical trials at Eli Lilly and Novo Nordisk here: GLP-1 drugs also include a warning about the risks of thyroid cancer that have been observed in animal studies
NutrMetab (Lond)
[PMID: 41665299] PubMed record related to this compound for laboratory literature review
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