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The compound's sequence is short enough that the four residues span the entire peptide

The cannabinoid-mediated reduction in neurotransmitter release is achieved by the reduced influx of presynaptic Ca 2+ due to the inhibition of voltage gated Ca 2+ channels and of adenylyl cyclase, which downregulates cyclic adenosine monophosphate and protein kinase A, two cellular constituents involved in increasing the influx of Ca 2+ (Castillo et al., 2012)

Liotti L, Caimmi S, Bottau P, Bernardini R, Cardinale F, Saretta F, et al

However, the International Peptide Society has published two epithalon dosing protocols based on the extensive work of Professor Khavinson and colleagues

Studies are still ongoing for these claims