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recommended by NICE in Technology Appraisal TA1026 within defined clinical criteria and specialist weight management services Access to these medicines on the NHS is typically through specialist Tier 3 or Tier 4 weight management services, and local referral criteria apply
Joint and Muscle Aching: Systemic inflammation and the accumulation of lactic acid and other metabolic waste products in the tissues cause widespread pain
Dose increase: Dose may be increased to 25 mg orally once a day for patients tolerating therapy and requiring additional glycemic control
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Furthermore, the anti-inflammatory and antifibrotic effects of GLP-1RAs offer additional benefits in reducing liver injury and slowing fibrosis progression
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