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Blocking of system Xc--mediated cystine import using excessive glutamate results in GSH depletion and consequent ROS accumulation, ultimately leading to a void in the antioxidant defenses and lipid peroxidation that triggers ferroptosis (22)
Both reduce inflammation, but one does it at a point and one does it throughout the body
Acknowledgements The authors gratefully acknowledge the research contributions of all laboratories working on the canary in the coal mine male reproductive health paradigm and M
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