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It suffers from bioavailability issues, and the CNS-targeting theory remains unvalidated for this specific compound

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Many patients experience improvement as their body adjusts to the medication, though some require ongoing management strategies

However, with the prevalence of skin permeation enhancement methods (such as microneedles and laser) used in cosmetic and pharmaceutical industry 15 , copper compounds may pose a higher risk to cause skin irritation, which necessitates a thorough skin toxicity testing