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These alterations were accompanied by increased expression of Cas-3 and NF-B, elevated levels of pro-inflammatory cytokines (TNF-, IL-6), and significant oxidative stress, as evidenced by increased MDA and decreased antioxidant enzyme levels (SOD, CAT, GSH-Px)
By influencing these pathways, they may improve recovery, assist in developing more consistent sleep patterns, and support better overall performance
however, this inhibitory effect diminishes when concentrations increase to 50100 nM [60]
However, because FAERS does not account for total prescription volume, these differences should be interpreted cautiously and not as definitive risk comparisons
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