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Further, GLP-1RAs promote VSMC redifferentiation via AMPK/SIRT1/forkhead box O (FOXO3a) pathways, where the expression of contractile VSMCs markers (SM22 and Calponin) is increased [125]

ActRII Activin Type II

The main hypothalamic areas involved in the control of both hunger and satiety are the arcuate nucleus (ARC), the paraventricular nucleus, the dorsomedial and ventromedial hypothalamus, and the lateral hypothalamic area