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PMID 2738168
502 In mice with type 2 diabetes, sulforaphane inhibits ferroptosis by inducing Nrf2-mediated metallothionein expression, thereby preventing diabetes-related cardiac inflammation, oxidative damage, and hypertrophy
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doi:10.1016/0003-2697(78)90372-X
A comprehensive proteomic study of platelets in patients with T2DM and mild cognitive impairment (T2DM-MCI) versus those without (T2DM-nMCI) revealed that differentially expressed proteins are primarily involved in amyloidosis, mitochondrial autophagy, and insulin signaling pathways ( Meta-analyses on gray and white matter changes in T2DM patients with cognitive impairment have concluded that T2DM impairs cognitive function by affecting specific brain structures ( The relationship between diabetes and cognitive impairment involves many aspects, including central insulin signal transduction, nerve fiber damage caused by hyperglycemia, neuritis, oxidative stress, bloodbrain barrier damage, vascular neuropathy, changes in the dopaminergic system, and the effects of advanced glycation end products on metabolism and energy (Figure 1)
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