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Mechanism of Action Ipamorelin activates the growth hormone secretagogue receptor type 1a (GHS-R1a), also known as the ghrelin receptor, on pituitary somatotroph cells

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In patients with painful DPN, clinicians should offer tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, gabapentinoids and/or sodium channel blockers to reduce pain (Level B) and consider factors other than efficacy (Level B)

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