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Because the needle is extremely thin and short, it typically does not reach the nerve endings that cause significant pain, making it much more comfortable than traditional syringes

may escalate to 14 mg based on response Must be taken on an empty stomach with a small sip of water (120 ml) and wait 30 minutes before eating, drinking or taking other oral medicines For semaglutide (Wegovy) used in weight management: Gradual escalation over 1620 weeks, starting at 0.25 mg weekly Target maintenance dose: 2.4 mg once weekly Some patients may remain on 1.7 mg if 2.4 mg is not tolerated For dulaglutide (Trulicity) : Starting dose: 0.75 mg once weekly Can be increased to 1.5 mg, 3 mg, or 4.5 mg weekly depending on response For liraglutide (Victoza) in diabetes: Starting dose: 0.6 mg daily for at least one week Maintenance: 1.2 mg daily, with possible increase to 1.8 mg For liraglutide (Saxenda) in weight management: Gradual weekly increases from 0.6 mg to a target of 3 mg daily All GLP-1 medications follow a dose-escalation protocol to minimise gastrointestinal side effects such as nausea, vomiting, and diarrhoea

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Injection protocols for TFCC target the ulnar wrist area, subcutaneously placed over the depression between the ulnar styloid and the fifth metacarpal base