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doi: 10.1111/jcmm.15489 107

Similar content being viewed by others Subjects Introduction Chronic stress, encompassing conditions such as hypertension, is widely recognized for leading to adverse cardiac remodeling and subsequent heart failure (HF), a condition with high rates of mortality and morbidity 1

Moreover, although randomized designs mitigate healthy-user bias, participants enrolled in long-term cardiovascular outcome trials may represent a healthier, more adherent subset of patients, potentially limiting generalizability

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This review examines how modern lifestyle factors drive oxidative stress that contributes to chronic diseases like cardiovascular disease, diabetes, neurodegeneration, and cancer