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In these cases, once the disease is established, the majority of the 70,000 hypocretin-producing cells have been destroyed, and the disorder is irreversible

J Glaucoma 33:S75S77 Thapa S et al (2021) Glaucoma in developing countries

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However, its use is under ethical scrutiny and may violate anti-doping regulations in competitive sports.

Additional safety monitoring for tirzepatide includes: Risk of hypoglycemia when used with insulin or insulin secretagogues (sulfonylureas)