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The most common AEs with semaglutide were gastrointestinal in nature and were mostly mild and comparable in frequency to what has been reported in other populations 16,17
Contraindications Noted in Published Research Because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, the literature consistently identifies active or prior malignancy, and precancerous conditions, as contraindications for IGF-1 LR3 research use
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