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Animal studies are limited and human data are lacking, making it difficult to assess potential risks to the fetus or nursing infant

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Although many of these studies involved supplement blends, the consistent results suggest that L-arginines effect on vascular and endothelial function may be a key contributor

Under conditions with overwhelming nitrosative stress, the signalling kinase pathway phosphoinositide-3-Kinases/v-Akt murine thymoma viral oncogene (PI3K/AKT) is involved in the activation of Nrf2 and the Nrf2-dependent genes [66]

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