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Both changes sit in the region that IGF binding proteins recognise, so the analogue binds IGFBPs far more weakly than IGF-I while retaining high affinity at the type 1 IGF receptor
Torriani, S
D.ZhangE
Similarly, melatonin, procyanidin B2, quercetin, and spermidine have been associated with increased expression of LC3-II and Beclin-1, suggesting enhanced autophagic flux and improved granulosa cells viability under oxidative stress conditions (Zhang et al., 2016
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