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In participants with overweight/obesity with and without type 2 diabetes, injected semaglutide similarly reduced LDL by up to 7%, triglycerides by up to 18%, and c-reactive protein by up to 25% in association with reductions in cardiovascular outcomes [9, 16]

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However, in clinical trials, approximately 4-7% of participants stopped taking semaglutide due to gastrointestinal adverse effects

Spinelli M, Fusco S, Grassi C (2019) Brain insulin resistance and hippocampal plasticity: mechanisms and biomarkers of cognitive decline

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